Endocrine Abstracts

Background: It is well known that both genetic backgroup and lifestyle influence the development of ‘general’ obesity. However, the role of parental body mass index (BMI) on the development of obesity in long-term survivors of childhood-onset craniopharyngioma (CP) is not well understood. This study aimed to analyze the correlation of patients’ BMI at diagnosis, and last visit and parental BMI at CP diagnosis and further explored potential risk factors for obesi...

Introduction: To reliably assess glomerular filtration is of vital importance if oral antidiabetics are used. We compared the CKD-EPI model, a clinically established calculation model to assess creatinine clearance (CreaClear) with specimens from 24-h urine.Method: Inpatients (university hospital) with diabetes mellitus received a 24-h urine collection (24hClear) or since 2013 calculated CreaClear using CKD-EPI-formula (EPI). From 2014 to 2015 values of ...

Introduction: Pituitary surgery is the first line treatment for most patients with Cushing’s disease (CD) but after failure or recurrence after surgery 3 main strategies can be proposed: medical treatment (MT), a 2 nd pituitary surgery, bilateral adrenalectomy (BA). Pituitary radiotherapy is a 4th strategy, generally combined with one of the 3 others. Medical treatment (MT) emerges as an attractive strategy but there are little data on long-term control after f...

Background: The Covid-19 pandemic caused by the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) determined millions of deaths worldwide, thus at the end of 2020 a massive vaccination campaign has been launched. SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT), Graves’ disease (GD) and orbitopathy (GO). We studied the occurrence of SAT and GO following SARS-CoV-2 infection or vaccinati...

Introduction: The humanized antibody anti-CD52+ alemtuzumab has been approved since 2014 for the treatment of relapsing-remitting multiple sclerosis (RRMS). Immune reconstitution after alemtuzumab induces thyroid autoimmunity in 34-41% of patients with RRMS, with Graves’ disease (GD) accounting for 63-65% of cases. Graves’ Orbitopathy (GO) may also occur in 13% of patients after alemtuzumab and is scarcely reported. Here we present the first case of alemtuzumab-induc...

Background: Vaccination is a widely adopted measure against the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) causing Covid-19 pandemic. Both SARS-CoV-2 infection and Covid-19 vaccines have been associated with several thyroid disorders. We studied the risk of Graves’ orbitopathy (GO) following Covid-19 vaccination.Methods: The study included 98 consecutive patients (71 females and 27 males, mean-age 50 years) attending our tertiary r...

Background: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of PI3K/Akt signaling and its related molecules (IRS-1/Akt/AS160) as well as reduced glucose uptake. Subjects with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling disruption in vivo and in vitro. Oregano (Origanum vulgare L.) is a plant u...

Background: Proton beam therapy (PBT) compared to photon-based radiotherapy (XRT) offers the benefit to administer lower radiation doses to critical organs thereby possibly minimizing the risk of sequelae in patients with residual craniopharyngiomas (CP) after hypothalamus-sparing surgery. The validation in large CP patient cohorts is still pending. Methods: Of 290 childhood-onset CP patients included 2007-2019 in the prospective multicenter trial Kranio...

Introduction: 2 to 3% of the causes of hypoglycemia in the population without diabetes mellitus correspond to tumors of cells other than islets. Below is a rare case of hypoglycemia related to a pleural tumor. Clinical case: A 65-year-old woman with arterial hypertension, psychiatric treatment for confusion and behavioral changes of 6 months of evolution, palpitations and night sweats, loss of 20 kg of weight, several admissions to the emergency room, un...

Objective: Hypothalamic syndrome (HS) in childhood is a rare condition. Its epidemiology is not well known because incidence and prevalence are related to very rare underlying diseases. In addition, different criteria for the syndrome are used across studies. Recognizing HS may be difficult, due to its rareness and variety of symptoms. Having diagnostic criteria for signs and symptoms of hypothalamic dysfunction may aid in early recognition and diagnosis, in the reporting and ...